Significance of lactate clearance in septic shock patients with high bilirubin levels

Abstract Lactate clearance is affected by hepatic function. However, it unclear whether the association between dysfunction and lactate can act as a prognostic marker of clinical outcomes in patients with septic shock. We aimed to evaluate mortality two cohorts shock patient who had based on their total serum bilirubin levels (TBIL). at 24 h after onset was analyzed using cohorts, sub-categorized into groups TBIL: < 2 mg/dL ? mg/dL. In derivation cohort, lower non-survivors than survivors TBIL mg/dL, while there no significant difference Multivariate logistic regression analysis revealed that increased significantly associated decreased 28-day group (10% clearance, adjusted odds ratio [OR]: 0.88, 95% confidence interval (CI): 0.80–0.97, P = 0.0075), Creatinine level (adjusted OR: CI: 0.81–0.95, 0.00069) APACHE II score 35 0.93, 0.87–0.98, 0.013). validation observed Increased 0.89, 0.83–0.96, 0.0038) just about 0.86, 0.74–1.00, 0.051). conclusion, (TBIL mg/dL) or high severity (APACHE 35) mortality.